Research
Charalambos Antoniades MD PhD
Collaborators
- Prof Keith Channon
- Prof Barbara Casadei
- Prof Robin Choudhury
- Dr Paul Leeson
- Prof Adrian Banning
- Dr Rajesh Kharbanda
- Dr Cheerag Shirodaria
- Dr Kim Dora
- Dr Zsolt Bagi
Selected Publications
- Antoniades Charalambos, Demosthenous Michael, Reilly Svetlana, Margaritis Marios, Zhang Mei-Hua, Antonopoulos Alexios, Marinou Kyriakoula, Nahar Keshav, Jayaram Raja, Tousoulis Dimitris, Bakogiannis Constantinos, Sayeed Rana, Triantafyllou Costas, Koumallos Nikolaos, Psarros Costas, Miliou Antigoni, Stefanadis Christodoulos, Channon Keith M, and Casadei Barbara (2012) Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. J Am Coll Cardiol, 59(1):60-70.
- Van-Assche Tim, Huygelen Veronique, Crabtree Mark J, and Antoniades Charalambos (2011) Gene therapy targeting inflammation in atherosclerosis. Curr Pharm Des, 17(37):4210-23.
- Antoniades Charalambos, Bakogiannis Constantinos, Tousoulis Dimitris, Reilly Svetlana, Zhang Mei-Hua, Paschalis Andreas, Antonopoulos Alexios S, Demosthenous Michael, Miliou Antigoni, Psarros Costas, Marinou Kyriakoula, Sfyras Nikolaos, Economopoulos George, Casadei Barbara, Channon Keith M, and Stefanadis Christodoulos (2010) Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation, 122(11 Suppl):S66-73.
- Antoniades Charalambos, Antonopoulos Alexios S, Tousoulis Dimitris, Marinou Kyriakoula, and Stefanadis Christodoulos (2009) Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J, 30(1):6-15.
- Antoniades Charalambos, Shirodaria Cheerag, Leeson Paul, Baarholm Otto A, Van-Assche Tim, Cunnington Colin, Pillai Ravi, Ratnatunga Chandi, Tousoulis Dimitris, Stefanadis Christodoulos, Refsum Helga, and Channon Keith M (2009) MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation, 119(18):2507-15.
| charalambos.antoniades@cardiov.ox.ac.uk | |
| Tel | +44 (0) 1865 221870 |
| Fax | +44 (0) 1865 740352 |
| Contact address | Department of Cardiovascular Medicine, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom |
| Department | Department of Cardiovascular Medicine |
The interplay between adipose tissue and vascular/myocardial redox signalling
Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system.
Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across Europe, and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation.
In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production.
Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease.
Local Collaborators: Professor Keith Channon, Professor Barbara Casadei, Professor Robin Choudhury, Dr Paul Leeson, Professor Adrian Banning, Dr Rajesh Kharbanda, Dr Cheerag Shirodaria (Covance Inc.), Dr Kim Dora, Dr Zsolt Bagi
National/International Collaborators: Professors Dimitris Tousoulis and Christodoulos Stefanadis (Cardiology Department, University of Athens), Professor Michael Koutsilieris and Dr Kyriakoula Marinou (Experimental Physiology, University of Athens), Professor Thomasz Guzik (Jagiellonian University of Krakow), Dr An Moens (Dept. of Cardiology, Maastricht University Medical Centre)
