Research
Oliver Rider BA MRCP DPhil
Collaborators
- Professor Stefan Neubauer
- Professor Kieran Clarke
- Dr Damien Tyler
Selected Publications
- Rider Oliver J, Francis Jane M, Ali Mohammed K, Holloway Cameron, Pegg Tammy, Robson Matthew D, Tyler Damian, Byrne James, Clarke Kieran, and Neubauer Stefan (2012) Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation, 125(12):1511-9.
- Rider Oliver J, Petersen Steffen E, Francis Jane M, Ali Mohammed K, Hudsmith Lucy E, Robinson Monique R, Clarke Kieran, and Neubauer Stefan (2011) Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity. Heart, 97(3):203-8.
- Rider Oliver J, Francis Jane M, Ali Mohammed K, Petersen Steffen E, Robinson Monique, Robson Matthew D, Byrne James P, Clarke Kieran, and Neubauer Stefan (2009) Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity. J Am Coll Cardiol, 54(8):718-26.
| oliver.rider@cardiov.ox.ac.uk | |
| Tel | +44 1865 221867 |
| Contact address | Department of Cardiovascular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU |
| Department | Department of Cardiovascular Medicine |
The Effect of Obesity and Weight Loss On the Cardiovascular System
Obesity is becoming worldwide epidemic in adults and children and is set to supersede smoking as the primary cause of morbidity and mortality in the next decade. Obesity had been implicated in many cardiovascular diseases, e.g. hypertension, coronary artery disease, and heart failure and is an independent risk factor for cardiovascular mortality. However, most studies into the effect of obesity are done on obese subjects who have concomitant diabetes, insulin resistance or hypertension- pathologies that exert independent cardiovascular effects. Therefore, separating the effects of obesity per se on the cardiovascular system is challenging.
Obesity, without co-morbidities, is characterized by elevated cardiac mass, diastolic dysfunction, impaired myocardial energetics, elevated intra-myocellular lipid content and increased aortic stiffness, all of which are associated with negative cardiovascular outcomes. By studying these adaptations to excess fat, this group aims to further understand the ways in which obesity adversely, effects the cardiovascular system.
Weight loss improves mortality, but the reasons behind this are not known. In order to further the understanding of the mechanisms behind this, we study the effects of both surgical (bariatric) weight loss and dietary weight loss on cardiovascular structure and function.
This group studies the effects of obesity without co-morbidities and subsequent weight loss on cardiovascular function and metabolism, using rest and stress cardiovascular magnetic imaging and 31P and 1H spectroscopy techniques.
