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Paul Leeson PhD, MRCP, FESC

Honorary Consultant Cardiologist and BHF Senior Clinical Research Fellow
Clinical Lead, Oxford Cardiovascular Clinical Research Facility
Cardiovascular Imaging and Early Development of Cardiovascular Disease

Research Themes

Divisional Themes

  • Cardiovascular Science

Selected Publications

Email
Tel +44 (0) 1865 572846
Fax +44 (0) 1865 572842

Prevention of Cardiovascular Disease and Hypertension

We use cardiac and vascular imaging, in conjunction with laboratory-based studies, to characterise early patho-physiological changes that predispose to cardiovascular diseases, such as, hypertension. The work aims to identify and trial novel primary prevention strategies. We have a particular focus on how preeclampsia increases risk of later cardiovascular disease, for both mother and child, as well as how perinatal interventions can modify long term risk in adulthood.

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Within the Oxford Cardiovascular Clinical Research Facility we use a range of complementary techniques, including echocardiography, ultrasound, tonometry, microscopy and venous occlusion plethysmography. These allow us to quantify variation in cardiac and vascular biology and physiology in children and adults. These measures are combined with magnetic resonance assessment of pathology. We study potential underlying mechanisms for early disease development with laboratory-based cellular, molecular and genetic work. We currently have both observational studies and clinical trials in progress, and have a large, established vascular tissue bioresource to aid investigation of underlying mechanisms.

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Cardiovascular Imaging

Our refinement of clinical imaging techniques and analysis approaches within the Oxford Cardiovascular Clinical Research Facility, in collaboration with the Institute of Biomedical Engineering, has created opportunities to contribute as an expert laboratory to other cardiovascular research locally and internationally in areas as diverse as stress echo, sleep apnoea, Marfan syndrome and depression.

 

Group Members

The group currently comprises of core technical and research nurse staff, as well as clinical research fellows, postgraduates and undergraduate students.